The involvement of antigen processing in determinant selection by class II MHC and its relationship to immunodominance
Identifieur interne : 004605 ( Main/Exploration ); précédent : 004604; suivant : 004606The involvement of antigen processing in determinant selection by class II MHC and its relationship to immunodominance
Auteurs : Hongkui Deng [États-Unis] ; Lisa Fosdick [États-Unis] ; Eli Sercarz [États-Unis]Source :
- APMIS [ 0903-4641 ] ; 1993-07.
English descriptors
- Teeft :
- Acad, Antigen, Antigen complexed, Antigen presentation, Antigen processing, Antigenic, Antigenic peptides, Autoimmune, Autoimmune disease, Cell biol, Cell biology, Cell determinants, Cell epitopes, Cell hybridomas, Cell recognition, Cell repertoire, Cell response, Chimeric peptide, Cryptic determinants, Deng, Determinant, Determinant expression, Determinant influences, Determinant selection, Different types, Dominant determinant, Dominant expression, Endogenous, Endogenous antigen presentation, Endogenous antigens, Exogenous, Histocompatibility, Immune, Immune response, Immunodominance, Immunogenic peptides, Immunol, Initial processing, Intact proteins, Intracellular transport, Intramolecular competition, Invariant chain, Large antigen fragments, Large fragments, Limited number, Long peptides, Macrophage, Major histocompatibility, Molecular context, Molecule, Natl, Negative selection, Peptide, Peptide binding, Personal communication, Possible determinants, Possible mechanisms, Proc, Protein antigen, Recent studies, Recent study, Same compartment, Same molecule, Selective process, Sercarz, Single determinant, Subcellular fractions, Subdominant, Subdominant determinants.
Abstract
The T cell response in vivo to many whole proteins is focused on a limited number of possible determinants which can be termed immunodominant. Antigen processing for class II antigen presentation appears to play a major role in this selective process. With experimental evidence accumulated in our laboratory as well as others, we review several possible mechanisms involved in antigen processing responsible for selective or differential determinant expression. In particular, we discuss the determinant capture model in which MHC class II molecules initially capture large antigen fragments, such that bound determinants are protected from proteolysis by the MHC molecules and eventually become dominant while the flanking determinants are trimmed away. Such flanking determinants therefore become subdominant or cryptic. This mechanism underlies the capturing role of MHC molecules in the physiological processing of antigens.
Url:
DOI: 10.1111/j.1699-0463.1993.tb00161.x
Affiliations:
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Antigen processing for class II antigen presentation appears to play a major role in this selective process. With experimental evidence accumulated in our laboratory as well as others, we review several possible mechanisms involved in antigen processing responsible for selective or differential determinant expression. In particular, we discuss the determinant capture model in which MHC class II molecules initially capture large antigen fragments, such that bound determinants are protected from proteolysis by the MHC molecules and eventually become dominant while the flanking determinants are trimmed away. Such flanking determinants therefore become subdominant or cryptic. 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